Sex hormone androgen-based prostate cancer therapy risks heart disease: Study

The common treatment against prostate cancer, androgen-deprivation therapy (ADT) can worsen heart risk factors and may increase the risk of heart attack and/or cardiac death, according to a science advisory published in Circulation: Journal of the American Heart Association and CA: A Cancer Journal for Clinicians.

Data show that androgen-deprivation therapy can increase fat mass, increase low-density lipoprotein (LDL) cholesterol — the “bad” cholesterol — and cause blood sugar abnormalities.

“Based on current data, it was appropriate to conclude that there may be a relationship between ADT therapy in patients with prostate cancer and future cardiovascular risk,” said Glenn N. Levine, M.D., chair of the advisory writing group and professor of medicine at Baylor College of Medicine in Houston.

The advisory, produced by a writing group of experts from the American Heart Association, American Cancer Society and American Urological Association, and endorsed by the American Society for Radiation Oncology, is an evaluation of published research about the relationship between androgen-deprivation therapy and cardiovascular events and risk factors in patients with prostate cancer.

An increased risk with ADT was noted in 1 percent to 6 percent of the study populations. Thus, “while there may be some increased heart risk, the decision about whether to initiate androgen-deprivation therapy should be based on weighing the benefits of therapy with this potential modest risk,” he said.

Decisions about androgen-deprivation should be made by the physician treating the patient for prostate cancer without referral to other specialists, according to the advisory.

However, given the metabolic effects of androgen-deprivation therapy, patients receiving ADT should be followed periodically by their primary care physicians.

Patients with known heart disease should always be encouraged to adopt healthy lifestyle changes and receive the appropriate preventive therapies if necessary, including lipid-lowering, blood pressure-lowering, glucose-lowering therapy and antiplatelet therapies (such as aspirin), Levine said.

However, the relationship between androgen-deprivation therapy and heart attack or cardiac death has not been definitively established.

While some studies have found an association between ADT and increased cardiovascular risk, other studies have not detected the association, according to the advisory.

The writing group called for future studies to prospectively analyze heart risks related to androgen-deprivation therapy whenever possible.

Headquartered near Baltimore, Maryland, the American Urological Association is the pre-eminent professional organization for urologists, with more than 16,000 members throughout the world. An educational nonprofit organization, the AUA carries out a wide variety of programs for members and their patients.

The American Cancer Society is the nation’s largest non-governmental investor in cancer research, contributing about $3.4 billion.

The American Heart Association is the oldest and largest voluntary health organization.