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New marine-origin antibacterial molecule to treat multi-drug resistant infections safe: Piramal Life

Thursday, September 17, 2009, 15:53 This news item was posted in Discoveries category and has 0 Comments so far.

Piramal Life presents safety data of new antibacterial drug to treat multi-drug resistant infections

Piramal Life Sciences, the research arm of leading Indian generic company Piramal Healthcare, has presented safety and efficacy data of its new anti-bacterial molecule PM181104 to treat multi-drug resistant infections.

Piramal Life sciences presented the preclinical pharmacological data pertaining to a novel injectable antibiotic named PM181104 discovered and developed in house at the 49th Scientific Session of Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) being convened at San Francisco, California, USA.

Piramal Life Science’s novel injectable antibiotic PM181104 is a peptide molecule derived from a marine sponge-associated microorganism. This particular marine sponge was obtained from National Institute of Oceanography (NIO) under an ongoing collaboration between Piramal Life Sciences, and NIO.

“It is a moment of great pride for an Indian pharmaceutical company that its work will be presented at such a prestigious international scientific conference to discuss the results on the efficacy and safety of a molecule discovered in India,” said Dr Swati Piramal, director – Strategic Alliances and Communications, Piramal Group, at the ICAAC conference.

Piramal Life Science in-house screening of the natural product library resulted in the discovery of this new antibiotic compound.

Piramal Life has a diverse collection of natural product extracts from microbes and plants from rare habitats in India. Discovery efforts are also directed towards evaluating and investigating medicinal extracts and preparations from herbs and plants used by tribals and cited in ancient ayurvedic texts.

Multidrug resistant bacteria poses a serious threat to public health throughout the world. Approximately 126,000 hospitalizations in US are due to MRSA with 19,000 deaths yearly. The incidences of VRE infections among hospitalized patients have increased rapidly as well. There is an urgent need to discover new drugs that can be used to treat patients infected with multi drug resistant bacteria such as MRSA & VRE.

Piramal Life Sciences Limited is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly know as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL.

Piramal life is focused on four therapeutic areas – cancer, diabetes, inflammation and infectious diseases.

Piramal Life’s drug discover pipeline includes fourteen compounds. Of them four molecules are in different stages of clinical trials.

Piramal life’s lead chemical compound, a Cdk-4 inhibitor, has completed two phase studies and is being tested in another phase I/II trials for multiple myeloma.

Piramal Life cancer molecule P276 for pancreatic, and head and neck cancer has recently received regulatory approval by Drug Controller General of India (DCGI) for the initiation of two phase-I/II combination studies.

P276 is an inhibitor of key enzymes involved in the uncontrolled division and multiplication of cancer cells. It is being developed for the treatment of cancers for which there are inadequate treatment options. Multiple phase II, and Phase I/II trials are ongoing in USA, and India.

Piramal life started phase II trial of P 276 in USA in January to treat Mantle cell Lymphoma (MCL) and it is the second IND approved by the US FDA for this compound.

P-1446A-05, another cancer compound from Piramal Life Sciences Limited is currently in phase-I study in India. P-1446A-05 is an orally active molecule being developed for the treatment of cancer. P-1446A-05 is an inhibitor of key enzymes involved in the uncontrolled division and multiplication of cancer cells.

In August Piramal Life Sciences announced the completion of a phase I study of a new, orally active glucoselowering compound, P1736, in The Netherlands. P1736 is a non-PPARgamma insulin sensitizing compound and is being developed for the treatment of Type II diabetes. In the phase I trial single and multiple ascending dose studies were conducted in 30 and 22 healthy volunteers respectively, in The Netherlands.

Piramal Life has drug discovery and developments agreements with Eli Lilly & Company and Merck & Company.

Piramal Life Sciences commenced phase I trial of a new experimental drug molecule P2202 for diabetes-metabolic syndrome in Canada in May. P2202 is the second compound from Eli Lilly & Co. (USA) and is part of the collaborative agreement between the two companies and is being developed for diabetes-metabolic syndrome.

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