A faster-acting cream to treat erectile dysfunction or sexual impotence without causing side-effects in men may well be on its way to global markets.
New cream for erectile dysfunction can give erections instantly to men and much faster than the anti-impotence pill Viagra and that too without the worrying side-effects of Viagra.
Viagra pills for erectile dysfunction can take 30 minutes to an hour before taking effect.
Viagra pills contain phosphodiesterase inhibitors. Phosphodiesterase inhibitors which is the main active ingredient in Viagra and other drugs in the same class allow blood to flow more freely by helping arteries to relax. They do this by blocking the effects of an enzyme called phosphodiesterase type 5. These Viagra drugs can cause side effects ranging from headaches to vision problems and more serious complications.
Viagra pills, moreover, are not advised to men who have previously suffered a stroke or a heart attack are warned to take the medication with caution.
New erectile dysfunction cream being developed by a team of researchers from the Albert Einstein College of Medicine at Yeshiva University, New York, delivers the drugs straight to the affected area with nanoparticles contained in a lotion.
“The response time to the nanoparticles was very short, just a few minutes, which is basically what people want from erectile dysfunction medicine,” according Kelvin Davies, co-author of the study published in the journal Sexual Health.
Erectile dysfunction cream using nano particle delivery method has been found successful in nine out of 10 cases in studies using rodents.
Erectile dysfunction cream has also been found causing no serious side-effects to the body as the researchers applied the nanoparticles at therapeutic doses.
Erectile dysfunction drugs including Viagra, Cialis and Levitra do carry the risk of certain side effects, such as headaches, blurred vision, or upset stomach.
Erectile dysfunction cream would allow treatments would not lead to such unwanted side-effect because they focus on one part of the body, rather than dispersed throughout, as its does with Viagra pills.
Effects of nanoparticles containing other drugs such as Cialis, sialorphin, and nitric oxide, among 11 rats with erectile dysfunction, by the researchers.
Erectile dysfunction pills may have been used by tens of millions of men so far, mostly with great success.
However, pills containing Viagra drugs are not always effective. At least, one in three men reports that Vigara pills do not work for them.
The new erectile dysfunction cream is expected to reach market in 10 years time.
Erectile dysfunction, also called “impotence,” is the repeated inability to get or keep an erection firm enough for sexual intercourse. Erectile dysfunction is estimated to be occurring in a range from 15 million to 30 million men around the world.
Every 1,000 men in the United States, 7.7 physician office visits were made for erectile dysfunction in 1985. By 1999, that rate had nearly tripled to 22.3. The increase happened gradually, presumably as treatments such as vacuum devices and injectable drugs became more widely available and discussing erectile function became accepted, according to the National Ambulatory Medical Care Survey (NAMCS).
Erectile dysfunction (ED) is commonly due to damage to nerves, arteries, smooth muscles, and fibrous tissues. Diseases—such as diabetes, kidney disease, chronic alcoholism, multiple sclerosis, atherosclerosis, vascular disease, and neurologic disease—account for about 70 percent of ED cases. Between 35 and 50 percent of men with diabetes experience ED.
Lifestyle choices that contribute to heart disease and vascular problems also raise the risk of erectile dysfunction. Smoking, being overweight, and avoiding exercise are possible causes of ED.
Surgeries (especially radical prostate and bladder surgery for cancer) can injure nerves and arteries near the penis, causing ED. Injury to the penis, spinal cord, prostate, bladder, and pelvis can lead to ED by harming nerves, smooth muscles, arteries, and fibrous tissues of the corpora cavernosa.
In addition, many common medicines—blood pressure drugs, antihistamines, antidepressants, tranquilizers, appetite suppressants, and cimetidine (an ulcer drug)—can produce ED as a side effect.
Experts believe that psychological factors such as stress, anxiety, guilt, depression, low self-esteem, and fear of sexual failure cause 10 to 20 percent of ED cases. Men with a physical cause for ED frequently experience the same sort of psychological reactions (stress, anxiety, guilt, depression).
Other possible causes are smoking, which affects blood flow in veins and arteries, and hormonal abnormalities, such as not enough testosterone.
In March 1998, the Food and Drug Administration (FDA) approved Viagra, the first pill to treat ED. Followed by this, vardenafil hydrochloride (Levitra) and tadalafil (Cialis) have also been approved.
Viagra, Levitra, and Cialis all belong to a class of drugs called phosphodiesterase (PDE) inhibitors. Taken an hour before sexual activity, these drugs work by enhancing the effects of nitric oxide, a chemical that relaxes smooth muscles in the penis during sexual stimulation and allows increased blood flow.
The recommended dose for Viagra is 50 mg, and the physician may adjust this dose to 100 mg or 25 mg, depending on the patient. The recommended dose for either Levitra or Cialis is 10 mg, and the physician may adjust this dose to 20 mg if 10 mg is insufficient. A lower dose of 5 mg is available for patients who take other medicines or have conditions that may decrease the body’s ability to use the drug. Levitra is also available in a 2.5 mg dose.