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CANCER THERAPY SIDE-EFFECTS
 

Cancer therapy side effects: Chemo sessions affect brain functions


BY OUR PHARMA CORRESPONDENT

30 April,2007: New researches suggest that patients undergoing chemo sessions—the life saving treatment for cancer—can experience difficulties with their cognitive functions.

In contrast to earlier approach wherein physicians often rubbished symptoms including short-term memory loss, an inability to concentrate, difficulty retrieving words following chemo session as figments of imagination, there is now a widespread acknowledgment that patients with cognitive symptoms are not imagining things. Oncologists also are offering remedies, including stimulants commonly used for attention-deficit disorder and acupuncture.

Virtually all cancer survivors who have had toxic treatments like chemotherapy experience short-term memory loss and difficulty concentrating during and shortly afterward, experts say. But a vast majority improve. About 15 percent, or roughly 360,000 of the nation’s 2.4 million female breast cancer survivors, the group that has dominated research on cognitive side effects, remain distracted years later, according to some experts. And nobody knows what distinguishes this 15 percent, according to reports.

There is a concensus that the culprits include very high doses of chemotherapy, like those in anticipation of a bone marrow transplant; the combination of chemotherapy and supplementary hormonal treatments, like tamoxifen or aromatase inhibitors that lower the amount of estrogen in women who have cancers fueled by female hormones.

However, some researchers are of opinion that studies have been too small and lacked adequate baseline data to isolate a cause.

“So many factors affect cognitive function, and the kinds of cognitive problems associated with cancer treatment can be caused by many other things than chemotherapy,” said Dr. Ahles, the director of neurocognitive research at Memorial Sloan-Kettering Cancer Center in New York.

BY OUR PHARMA CORRESPONDENT

   

 

 

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