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Breast, colon cancer genes unravelled

Sequencing of these genes may lead to personalized medicine for cancers affecting breast and colon.


7 November,2006: The entire genetic sequence of breast and colon cancers gene have been mapped. Deciphering of this rather complex genetic code could lead to better ways to diagnose breast and colon cancers in their early, most treatable stages, as well as further develop personalised treatments.

Scientists from the Johns Hopkins Kimmel Cancer Center have produced a genetic map that shows nearly 200 mutated genes, most previously unknown, that help tumors emerge, grow and spread, says a study published in the Science magazine. 

The researchers discovered that mutated genes in breast and colon cancers were almost completely distinct, suggesting different pathways for the development of each of these cancer types. 

Each individual tumor appeared to have a different genetic blueprint, which could explain why cancers can behave very differently from person to person. 

It also gives rise to the concept of personalised treatments to treat this variation in the disease. "No two patients are identical," said co-author Dr Victor Velculescu in the report. 

Numerous genes play a role in drug response and toxicity, introducing a daunting level of complexity into the search for candidate genes. 

Personalised medicine or pharmacogenomic analysis can identify disease susceptibility genes representing potential new drug targets. This may well lead to novel approaches in drug discovery, an individualized application of drug therapy, and new insights into disease prevention. 

The breast cancer drug Herceptin targets a breast cancer cell receptor made by the Her2-neu gene. Blood tests for hereditary bowel cancer are based on the APC gene. 




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