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PHARMA - DRUG COMBO FOR HEART
ATTACK PREVENTION |
Drug duo halves heart attacks, strokes: Study
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BY OUR PHARMA CORRESPONDENT
8 September,2005: In a pathbreaking study,
Anglo-Swedish scientists reported the risk of
stroke and heart attacks in people with high blood
pressure could be halved by combining new
treatments such as Pfizer's Istin with cholesterol
lowering statins.
The study, presented at a European Society of
Cardiology meeting in Stockholm found that taking
a combination of the antihypertensives Istin (amlodipine)
and perindopril (made by France's Servier and
branded as Aceon) reduced the risk of stroke by
about 25 per cent, cardiovascular deaths by 25 per
cent and new cases of diabetes by 30 per cent,
compared with the standard treatment.
Peter Sever of the International Centre for
Circulatory Health at Imperial College, London
said the trial patients had high blood pressure
plus three additional risk factors, such as being
55, male and a smoker.
The addition of Pfizer's statin Lipitor found the
risk was further reduced, irrespective of the
patient's original cholesterol level.
With 9,000 of the study's patients being British,
it is likely to have major implications for the
treatment of hypertension by the NHS. The National
Institute for Health and Clinical Excellence,
which advises the NHS on new treatments is due to
meet with the British Hypertension Society to
discuss changing current guidelines.
The anti-hypertensives were compared with the
traditional treatment of a beta-blocker and a
diuretic.
BY OUR PHARMA CORRESPONDENT |
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