Home Politics Religion Media Biz Society Tech Travel Books Intl. Autos Automobiles
                        Aviation   Pharma   About Us   Feedback   Links

Viruses may help cure cancer by killing cancer cells



CALGARY, Alberta, June 28 /PRNewswire/ -- Researchers are now investigating how to make cancer cells "terminally ill" by giving a common reovirus to patients with various types of cancers.

Already in clinical trials, the reovirus-based therapy called "Reolysin" will soon be administered to patients at the Montefiore Medical Center in New York in a phase I trial sponsored by Calgary-based Oncolytics Biotech.

"Patients with cancers that have spread beyond their original tumor sites (metastatic) will receive the therapy via systemic, or intravenous administration," according to Oncolytics Biotech's chief scientific officer, Dr. Matt Coffey.

"This discovery -- that a common virus, even though it does not cause illness, can kill cancer cells -- offers hope for a truly revolutionary approach to cancer therapy," says Dr. George M. Gill, Senior Vice President of Clinical and Regulatory at Oncolytics.

As described by Dr. Coffey in published scientific journals, including Science and The EMBO Journal, reoviruses are able to replicate only in cancer cells with an activated Ras pathway, without harming healthy cells. The Ras Pathway is instrumental in transferring growth signals to the nucleus of a cell, telling the cell when and how to grow-much like an "on-off" switch.

A cell with an activated Ras Pathway, which has lost its ability to "turn off," leads to uncontrolled cell growth. These mutations along the Ras pathway are found in approximately two-thirds of all human cancers.

The virus in Reolysin will invade Ras-activated cancer cells, where the virus is able to replicate until it kills the host tumor cell. When the cancer cell dies, thousands of progeny virus particles are released, which then proceed to infect and kill adjacent cancer cells.

Dr. Coffey explains the process is believed to continue until all infected cancer cells with activated Ras pathways have been infected and killed by the reovirus -- all without causing the nausea, hair loss and other side effects associated with radiation and chemotherapy.

"In clinical trials completed to date, patients have not suffered any serious adverse side effects. Novel therapies like Reolysin are beginning to expand treatment options," says Dr. Coffey.


All cancer headlines

Drug for advanced colorectal cancer gets marketing nod in Canada
18 September,2005

Advanced prostate cancer therapy Provenge seeks marketing nod in US
18 September,2005

New kidney cancer drug seeks EU nod
13 September,2005

Breast cancer drug Aromasin approved in Europe: Pfizer  
15 Sep, 2005

Lung cancer vaccine trials promising: Introgen 
13 September,2005 

Rituxan, cancer drug can treat rheumatoid arthritis
2 September, 2005

Novartisí drug for breast cancer recurrence to be given priority review in US
31 August, 2005

New cancer combo therapy results positive: OXiGENE
25 August, 2005 

Cell Therapeutics to seek approval for lung cancer therapy in US and Europe
25 August, 2005

Aspirin stops colon cancer, but may trigger bleeding
24 August, 2005

Skin disease drug turns into anti-tumor therapy for cancer
22 August, 2005

"Breast cancer chances higher due to fried chips"
22 August, 2005

Pfizer files NDA for Sutent in US
13th August,2005

Alcohol linked cancers: Acetaldehyde in spot light
10 August, 2005

Chemokine gets US patent for novel cancer drug
20 June, 2005

Prohibitive costs mar cancer therapy
15 July, 2005

Viruses may help cure cancer by killing cancer cells
CALGARY, Alberta, June 28

Cervical Cancer detector may improve on Pap Smears
CHERRY HILL, N.J., June 28 

Novartis has better breast cancer treatment
Toronto, Ontario, April 11, 2005

Roche, Novartis lead on novel cancer therapies
23 July, 2005

Pfizer's investigational drug reduces tumor growth
14 May, 2005

   Pharma Home


Home Politics Religion Media Biz Society Tech Travel Books Intl. Autos Automobiles
                        Aviation   Pharma   About Us   Feedback   Links

Latest updates    Contact Us - Feedback    About Us